Low early ototoxicity rates for pediatric medulloblastoma patients treated with proton radiotherapy
نویسندگان
چکیده
منابع مشابه
Low early ototoxicity rates for pediatric medulloblastoma patients treated with proton radiotherapy
BACKGROUND Hearing loss is common following chemoradiotherapy for children with medulloblastoma. Compared to photons, proton radiotherapy reduces radiation dose to the cochlea for these patients. Here we examine whether this dosimetric advantage leads to a clinical benefit in audiometric outcomes. METHODS From 2006-2009, 23 children treated with proton radiotherapy for medulloblastoma were en...
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Manganese superoxide dismutase (MnSOD), encoded by the SOD2 gene, is involved in the detoxification of superoxide anion. Superoxide is likely a source of oxidative stress in the cochlea following treatment with platinum agents and radiation. Therefore, we examined SOD2 variants in association with ototoxicity among cisplatin-treated childhood medulloblastoma patients. Blood samples were obtaine...
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BACKGROUND To precisely calculate skin dose and thus to evaluate the relationship between the skin dose and permanent alopecia for pediatric medulloblastoma patients treated with proton beams. METHODS The dosimetry and alopecia outcomes of 12 children with medulloblastoma (ages 4-15 years) comprise the study cohort. Permanent alopecia was assessed and graded after completion of the entire the...
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Pediatric sarcomas represent a distinct group of pathologies, with approximately 900 new cases per year in the United States alone. Radiotherapy plays an integral role in the local control of these tumors, which often arise adjacent to critical structures and growing organs. The physical properties of proton beam radiotherapy provide a distinct advantage over standard photon radiation by elimin...
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ژورنال
عنوان ژورنال: Radiation Oncology
سال: 2011
ISSN: 1748-717X
DOI: 10.1186/1748-717x-6-58